Addictive Substances such as drugs and alcohol work by altering the levels of what in the brain?

you must remain stopped until the stop signal is retracted and the red lights are turned off. approaching traffic in the opposite roadway of a divided highway shall not be required to stop, even if the school bus has the stop-arm extended and the alternately flashing warning signal lamps on.

"1. it should be, it has been for about 20 years, and it's really not much different in the end than breeding animals to have particular traits. there are always concerns about genetically engineered animals/plants affecting the environment in unexpected negative ways, but i can't think of an example where the fears didn't turn out to be baseless.  

first, as you point out, it would be a great advance in pharmacology, to be able to tailor drugs and their doses to me. the pros involve better medical treatment. the cons involve privacy issues like insurance companies denying coverage to people with genetic risk factors. looking at dna markers wouldn't affect the frequency of genetic diseases, but it would allow detection of them earlier. and ok, actually i suppose that if people used this information to avoid having children with genetic diseases, some might decrease in frequency."

the answer would be knowledge about cars!

not too sure but maybe in the hot springs.