What if researchers followed a similar method used in this activity to calculate the correlation coefficients for the gene expression patterns of every patient with osteosarcoma and they found that all patients fell into two categories of gene expression patterns? What would this tell you about the single disease we call osteosarcoma? How might this information affect osteosarcoma cancer patient diagnosis and treatment in the future?

- Abnormal gene expression patterns can lead to osteosarcoma

- Different signaling pathways (at least two) are involved in osteosarcoma

- Differentially expressed genes might be promising biomarkers for early detection of osteosarcoma

Explanation:

Cancer can be defined as a group of genetic diseases that are characterized by uncontrolled/inappropriate cell growth. In general, cancer pathways are associated with abnormal expression of signaling components that disrupt the regulatory networks capable of controlling cell function, thereby cancerous cells can inhibit programmed death cell (apoptosis). Osteosarcoma is one type of cancer disease that starts in the bones, i.e., this disease may be triggered by overactivity of bone cells. Additionally, it is important to note that different immune-related genes were recently found to be dysregulated in osteosarcoma. For example, differentially expressed immune-related genes involved in PI3K/AKT, MAPK and JAK-STAT signaling pathways have shown prognostic value in this disease.

stimulus is a change in the environment that causes an organism to react. the response is the reaction to the stimulus. some examples of stimuli for zebras are drought, to many predators, and bad feeding grounds such as dead grass or plants. zebras respond to stimuli just like all other living organisms