Primary lateral sclerosis is a disease that affects the body's ability to react to stimuli and causes a person to have difficulty moving the legs, body trunk, arms, hands, and face. Which specialized cells are most affected by this disease?

epithelial cells, hepatocytes
neurons, epithelial cells
muscle cells, neurons
hepatocytes, muscle cells

The cells that are most affected by Primary Lateral Sclerosis are muscle cells and neurons.

Explanation:

Primary Lateral Sclerosis (PLE) is a condition that affects the portion of the peripheral nerves that are responsible for innervating the striated muscles, producing muscle stiffness and paralysis.

The cause of PLE is unknown and it produces a degeneration of the supporting tissue —glial tissue— in the lateral portion of the spinal cord and nerves, which is in charge of activating the muscle tissue. As a result, the cells most affected are the neurons, which do not fulfill their function, and the muscle cells that tend to atrophy.

The other answer combinations are wrong choices because:

sex cells are usually half's then they find another half and make a fertilize egg