Despite the human genome being significantly larger than the genome of bacteria such as E. Coli, it does not take a human cell significantly longer to replicate its genome. Why?

Rapidly and Accurately

Explanation:

As an example, eukaryotic human DNA replicates at a rate of 50 nucleotides per second.

Replication occurs so quickly because multiple polymerases, or think: enzyme+polymer=polymerase, can synthesize, or combine or fuse, two new strands at the same time by using each untwined strand from the original DNA double helix as a guide.

DNA replication is so much faster than bacteria replication because it's extremely difficult to replicate DNA accurately, as well as copying molecules that tightly complexed with histones in nucleosomes, which work together to form chromatin, which is the material that chromosomes are composed of, and it's further composed of protein (histones), DNA, and RNA.

Therefore, the reason for human cells taking significantly less time to replicate its genome is accuracy.

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