What makes nondisjunction the mutation with the most impact on an individual?

Nondisjunction is the failure of homologous chromosomes or chromatids to segregate during mitosis or meiosis. Nondisjunction during mitosis can result in cancer. Nondisjunction during meiosis results in one daughter cell having both of a pair of parental chromosomes with the other having none. It causes a mutation in the number of chromosomes, either extra chromosomes or missing chromosomes.

Explanation:

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each of the 46 original chromosomes splits into two daughter chromosomes, so there are two sets of 46 daughter chromosomes that end up in each cell. human cells have 46 chromosomes. each chromosome consists of a pair of identical chromatids attached together by a structure called a centromere.

it would be heredity