The image shows two types of diffusion movements in the phospholipid membrane. Lateral diffusion is the lateral movement of lipids within the membrane, and transverse (flip-flop) diffusion is the movement of lipids from one side of the membrane surface to the other. Membrane proteins also move through lateral and transverse diffusion. On the cell exterior, lipids are moving laterally. Lipids are also moving from one side of the cell membrane surface to the other (transverse or flip-flop).

Which of the following statements regarding membrane protein diffusion is true?

The orientation of protein polar regions will remain the same after lateral diffusion.
The orientation of protein polar regions will remain the same after transverse diffusion.
Lateral diffusion of proteins will disrupt the hydrophobic interactions within transmembrane proteins.
Lateral diffusion of proteins will disrupt protein interactions with the extracellular matrix and cellular cytoskeleton.