Individuals can take a course of antibiotics to their immune system fight bacterial diseases. which of the following best explains why these antibiotics may lose their effectiveness against certain bacteria?

antibiotics have become diluted and weak because of a limited supply.

resistant bacteria are polyploidy and can resist the antibiotic, a trait that is passed on to their offspring.

some bacteria have randomly mutated to resist the antibiotic, and this resistance is inherited.

bacteria have purposefully directed their immune system to resist the effect of the antibiotic.