In humans the mitochondrial genome encodes a low number of proteins, r RNA s, and t RNA s but imports approximately 1100 proteins encoded by the nuclear genome. Yet, with such a small proportion from the mitochondrial genome encoding proteins and RNA s, a disproportionately high number of genetic disorders due to mt DNA mutations have been identified (Bigger, B. et al. 1999). What inheritance pattern would you expect in a three-generation pedigree in which the grandfather expresses the initial mtDNA defect? What inheritance pattern would you expect in a three-generation pedigree in which the grandmother expresses the initial mt DNA defect?