The macrophages have a in the calcification process, which generates the inflammatory processes. The Ghon tubercles is a lung lesion caused in tuberculosis that consists of a focus of calcification in conjunction with a lymph node infection. A granuloma is a mass of immune cells that forms when the immune system tries to isolate foreign substances.Macrophages can be activated by a variety of stimuli during the immune response. The antigen-antibody (Ag-Ac) reaction is one of the molecular reactions in the body's immune response.
Explanation:
Tuberculosis is a disease caused by Mycobacterium tuberculosis, a bacterium that almost always affects the lungs. When the active form of the disease is present, symptoms (cough, fever, night sweats, weight loss, etc.) can be mild for many months. If not treated properly, Tuberculosis can be fatal.
Macrophages are a type of white blood cell found in the blood and they are the first body's defense against foreign substances. So they are effector cells of the immune system, the main players in the innate immune response.
When M. Tuberculosis infects a person, it attacks this first-response immune cells in the lungs, the macrophages. When they recognize these pathogens, macrophages produce the cytokines IL-1 and TNF-α, which cause the inflammation itself by acting on the endothelial cells of the nearby blood vessels to allow the transendothelial migration of the leukocytes. The inflammation t is a non-specific response to environmental aggressions, and its purpose is the isolation and destruction of the damaging agent, as well as repairing the damaged tissue or organ.
The macrophages have a in the calcification process, which generates the inflammatory processes. The Ghon tubercles is a lung lesion caused in tuberculosis that consists of a focus of calcification in conjunction with a lymph node infection. These lesions are especially common in children and may retain viable bacteria, so they are sources of disease transmission and may also be associated with classic tuberculosis reactivation after several years of inactivity.A granuloma is a roughly spherical mass of immune cells that forms when the immune system tries to isolate foreign substances that it has been unable to eliminate. Therefore it is a special type of inflammation that can occur in a wide variety of diseases. Infections that are characterized by granulomas include tuberculosis, but also include for example leprosy, histoplasmosis, cryptococcosis, coccidioidomycosis, blastomycosis, and cat scratch disease.Macrophages are usually in a resting state, they can be activated by a variety of stimuli during the immune response. Antigen phagocytosis serves as an initial stimulus; however, macrophages and their activity can be increased by cytokines secreted by, or through contact with, helper T-lymphocytes. One of the most powerful macrophage activators is gamma interferon. They are also able to recognize molecular patterns associated with pathogens. M. tuberculosis is a pathogen that contains Pathogen-associated molecular patterns (PAMPS), which are small sequences of molecules that repeat in groups of pathogens. They are recognised by Pattern-recognition receptors (PRRs), which include the Toll-like receptor (TLRs) family or the NOD-like receptors (NLRs). Once the receptors found in the macrophages recognize these PAMPS, the macrophages are activated are ready to perform an immune response.The antigen-antibody (Ag-Ac) reaction is one of the molecular reactions in the body's immune response. The concept refers to the specific binding of an antibody to an antigen to inhibit or delay its toxicity. When the macrophage recognizes a pathogen, it phagocytes it and degrades it, and presents its peptides to a T cell. This can activate a cytotoxic response, causing apoptosis of infected cells. Or, the T cell may activate a B cell to produce antibodies. Antibodies are proteins whose function is to detect any foreign elements that may enter the body. They normally detect specific parts of these elements, for example, proteins from the surface of bacteria or viruses. When antibodies bind to these foreign proteins, they act as a marker, making it easier for them to be recognised and eliminated by the cells of the immune system.
