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Biology, 07.07.2020 19:01 augestfaith
Imidazoleglycerol-phosphate dehydratase is an enzyme in the histine biosynthesis pathway. It catalyzes the E1 dehydration of D-erthyro-imidazole-glycerol phosphate to imidazole acetol-phosphate. This is a rare example of a biological E1 reaction, as most biological elimination reactions occur through E1cB instead. In this reaction, D-erthyro-imidazole-glycerol phosphate is first protonated to form a good leaving group. Then, the leaving group is ejected to form the resonance-stabilized carbocation below. Draw curved arrows forming the most stable resonance structure to explain why this reaction goes through an E1 mechanism.
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Imidazoleglycerol-phosphate dehydratase is an enzyme in the histine biosynthesis pathway. It catalyz...
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