Comparison of glycogen synthesis and breakdown in muscle and liver reveals: A. Stimulation of glycogen breakdown in both tissues by epinephrine leads to enhanced glucose uptake by liver cells and enhanced glucose export from muscle cells. B. Stimulation of glycogen synthesis by insulin in both tissues leads to glycogenolysis in both liver and muscle. C. Inhibition of glycogen synthesis in both tissues by epinephrine leads to glycogenolysis in both liver and muscle. D. Stimulation of glycogen synthesis by insulin in both tissues is accompanied by decreased glycogenolysis. E. Epinephrine stimulates glycogen uptake in liver and breakdown in muscle.

The correct options are C and D:

C- The inhibition of glycogen synthesis in both tissues by epinephrine leads to glycogenolysis in both the liver and muscle.

D- The stimulation of glycogen synthesis by insulin in both tissues is accompanied by a decrease in glycogenolysis.

Explanation:

The presence of epinephrine causes the glycogen reserve that is present in the liver and muscle to enter the glycogenolysis stage, that is, the chemical structures of glycogen are broken and simplified in energy coins (ATP) so that the activity muscle contract against stimulation of the adrenergic nervous system.

The adrenergic nervous system is one that promotes physical activity, physiological stress, flight from danger, and other activities, is also known as the sympathetic system and is where epinephrine or adrenaline predominates as a neurotransmitter.

The liver and muscle are the only possible organs to reserve glycogen in a limited way, once its reserve limits are exceeded it will begin to deposit in the form of adipose tissue, glycogenogenesis or formation of glycogen as reserve is promoted by insulin and the system parasympathetic nerve, visceversa to what we explained above with the sympathetic nervous system and epinephrine, since the latter break the glycogen reserves releasing glucose into the blood for muscle contraction.

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