Suppose the fictional condition lycanthropy is an autosomal dominant disorder that causes an affected person to have a strong physical reaction to the changing lunar cycle. Most cases of lycanthropy are due to spontaneous new mutations in the gametes of normal individuals. These new cases are due to a spontaneous mutation that occurs in paternal gametes, as opposed to maternal gametes. Additionally, the likelihood of this mutation occurring increases as the father ages.
Which of the following statements represent a related hypothesis for these findings?
a. Sperm undergo more mitotic cellular divisions than egg and therefore have a higher risk of developing a spontaneous mutation.
b. The average somatic mutation rate is higher in males than in females, therefore sperm have more mutations than eggs.
c. The mutation for lycanthropy may confer a benefit to the sperm, increasing the chance of survival when compared to a normal sperm.
d. The gene involved in lycanthropy may be in a mutational hotspot.
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