Evidence supporting E. coli DNA polymerase III having the major role in nucleotide incorporation during replication includes:

a) A point mutation can inactivate DNA pol III and inhibit replication.

b) DNA polymerase III has a high Vmax.

c) Replication is blocked at high temperatures in temperature sensitive mutants with a thermolabile form of DNA polymerase III.

d) There are ten or fewer molecules of enzyme per cell.

e) All of the above.