Knowledge of the driver mutations underlying cancer has led to targeted therapeutics, such as the protein kinase inhibitor imatinib (trade name Gleevec) in cases of chronic myeloid leukemia. Cancer cells often become resistant to a given drug, so researchers continue searching for new drugs that target proteins that contribute to the cancerous phenotype. One recent promising approach uses drugs that lead to ubiquitination and proteasomal degradation of the target protein. Which of the following mutated proteins are good candidates for this approach?Choose one or more:
A.) oncogenes
B.) proteins with loss-of-function mutations
C.) proteins with gain-of-function mutations
D.) tumor suppressor genes

A) and C.) Mutations in oncogenes and mutations in proteins with gain-of-function  

Explanation:

Mutations in oncogenes may trigger desired effects (for example, apoptosis in cancer cells), thereby resulting in the same effects such as those during the use of these drugs; while gain-of-function mutations of target genes may also enable to examine the effects of drugs that trigger ubiquitination and proteasomal degradation

b.

imagine a line passing through the center of earth that goes through both the north pole and the south pole. this imaginary line is called an axis. earth spins around its axis, just as a top spins around its spindle. this spinning movement is called earth's rotation. at the same time that the earth spins on its axis, it also orbits, or revolves around the sun. this movement is called revolution.