A number of experiments have demonstrated that areas of the genome that are relatively inert transcriptionally are resistant to DNase I digestion; however, those areas that are transcriptionally active are DNase I sensitive. Describe how DNase I resistance or sensitivity might indicate transcriptional activitA) When DNA is transcriptionally active, it is in a more condensed state and as such, more open to DNase digestion. B) When DNA is transcriptionally active, it is in a less condensed state and as such, more open to DNase digestion.

Option-B

Explanation:

DNase I is an enzyme which acts on the DNA in its single-stranded, double-stranded and chromatin form.

The DNase acting sites on the DNA is known as the DNA I hypersensitive site. The DNase I hypersensitive site allows the DNase I to act as the condensed form becomes less condensed.  This mechanism can be associated with the transcription as, during transcription, the DNA becomes less condensed and is open to DNase I enzyme.

Thus, Option-B is correct.

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