A novel antibiotic is under investigation for determination of safety margins. Concerns have been raised regarding potential hearing loss due to neurotoxicty. Based on early clinical trials, the median effective dose (ED50) is 10 mg/kg. Followup studies have found that median toxic dose (TD50) that is associated with hearing loss is 80 mg/kg. What is the therapeutic index for this novel antibiotic

Select the correct answer. which mutation is harmful to the organism? a. a mutation allowing moths to camouflage better on blackened tree bark b. a mutation making staphylococcus aureus resistant to the antibiotic methicillin c. a mutation inhibiting human immunodeficiency virus from attaching to and entering the cell d. a mutation causing uncontrolled cell division e. a mutation giving plant leaves a bitter taste to discourage herbivores from eating them