Which sensation would you become insensitive to if you lost your thermoTRP receptors?
A. The burn of chili peppers
B. The cooling sensation from mint
C. Pain associated with touching an extremely cold surface
D. Pain associated with touching an extremely hot surface
E. All of the above

option E

Explanation:

When the thermoTRP receptors become lost, one loses sensation to pain, temperature, different kinds of tastes, pressure, and vision. In the body, some TRP receptors act like microscopic thermometers  to detect hot or cold. Some TRP receptors become engaged by molecules found in spices like garlic, chili pepper. Others are activated by menthol, camphor, peppermint, and cooling agents. Some act as sensors of osmotic pressure, volume, stretch, and vibration, thus loss of these receptors will lead to insensitivity to the above listed sensations.

this protocol provides a detailed procedure for co-immunoprecipitation (co-ip) to identify protein–protein interactions.