The major advantages of a tissue-based compared to a mechanical-based heart valve prosthesis includes . .

A. resistance to structural dysfunction.
B. resistance to calcific mineralization.
C. reduced thrombogenicity.
D. pseudo-anatomic central fluid flow.

reduced thrombogenicity.

Explanation:

For patients with significant heart valve disease, surgical options for treatment include valve repair or replacement. The choice between repair and replacement is influenced by a number of factors including age, type of the valve disease and other medical conditions. When valve replacement is performed, there are options of mechanical or tissue heart valves. These two classes of valves confer different characteristics and each have their advantages and disadvantages.

Mechanical valves: Mechanical heart valves are made from materials such as titanium and carbon. They usually consist of two leaflets and a metal ring surrounded by a ring of knitted fabric, which is sewn onto the heart in place of the original valve.The main advantage of mechanical valves is that they are very durable. However, these valves provide a surface on which blood clots can form easily. As a result, anyone who has been implanted with a mechanical valve needs to be on lifelong blood-thinning medication, such as warfarin, to prevent the development of blood clots that can cause heart attack or stroke

Tissue valves, also known as biological or bioprosthetic valves, are composed of animal or human tissue. The valves are derived from animal tissue such as porcine (pig), bovine (cow) and equine (horse) models, and then fixed with a preserving solution that may be mounted on a flexible frame to assist in deployment during surgery. As with mechanical valves, the bottom of a tissue valve is often surrounded by a ring of knitted fabric that is sewn onto the heart. In addition to animal-derived valves, a human tissue valve from a donor human heart, known as an allograft or homograft, may also be used as a replacement valve. Tissue valves can be used in open heart surgery or in a minimally invasive aortic operation known as transcatheter aortic valve implantation (TAVI).

Advantages of tissue valves compared to mechanical valves include the avoidance of lifelong warfarin therapy to prevent the development of blood clots.

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