Suppose that we study a gene that has been linked to coronary heart disease. We find in a pilot study that in subjects with the C/ C genotype 20 events have occurred in 200 individuals over a period of 10 years, whereas in subjects with the T/ T genotype 30 events have occurred in 250 individuals in 10 years. Which genotype appears to be associated with a higher prevalence of heart disease?

T/ T genotype

Explanation:

To know which genotype appears to be associated with a higher prevalence of heart disease, you must know which genotype appeared in the highest percentage in the population tested.

For this, we will do the following calculations.

200 people = 100%

20 people = X

X = (20 * 100) / 200

X = 10%

This means that the C/C genotype appeared in 10% of the tested population.

Now we must to know the percentage of the T / T genotype, we must consider 200 of the 250 people tested.

250 people = 100%

200 people = x

X = (200 * 100) / 250

X = 80%

200 people = 80%

30 people = X

X = (30 * 80) / 200

X = 12%

Thus, we can say that the T / T genotype appeared in a higher percentage within the tested population, being considered the genotype that seems to be associated with a higher prevalence of heart disease.

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