The hives that Sally is experiencing are a result of an anaphylactic reaction. This is a multistep reaction resulting from the interaction of the wasp venom and Sally's immune system. Each of the statements below is a step in the anaphylactic response.
Arrange the following statements in the order that best represents the chronological order of events in generating an anaphylactic reaction.
1.IgE molecules bind to mast cells and basophils.
2. Antigen molecules cross-link adjacent IgE molecules.
3. Degranulation occurs.
4. Chemical mediators such as histamine are released.
5. Capillary permeability and smooth muscle contractions increase.
6. Neutrophils and eosinophils move to the site.
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