Do frame shift mutations cause big or small changes?

Nine months old i think but i’m not that sure

The need activity of the nurse is to suction discharges from the trachea. current treatment approaches in the pressing consideration facilities or crisis offices are corticosteroids and nebulized epinephrine; steroids have demonstrated advantageous in extreme, direct, and even gentle croup. in the clear instances of croup, anti-microbials are not endorsed, as the etiology is viral

Sugar + oxygen > carbon  dioxide + water + energy  c6h1206 + 6o2 > 6co2 +6h2o + energy  and the numbers after the element symbols are small.     

Where are the following