Lesch-Nyhan syndrome is an X-linked, recessive condition caused by mutation of the HPRT1 gene responsible for purine metabolism. The syndrome is characterized by juvenile-onset gout, involuntary muscle movements, and behavioral disorders. A mother and father have a young daughter who was diagnosed with Lesch-Nyhan syndrome. No one in the father\'s family was ever diagnosed with the syndrome. The mother\'s maternal grandfather was diagnosed with Lesch-Nyhan syndrome, but neither one of her parents was diagnosed with the condition. Select all the descriptions that could explain how their daughter inherited Lesch-Nyhan syndrome.
A. The mother's X chromosomes failed to separate during meiosis, and the daughter inherited two X chromosomes with the Lesch-Nyhan mutation. The father contributed no sex chromosomes.
B. The father did not contribute a sex chromosome to his daughter due to nondisjunction of the sex chromosomes. The daughter is XO and her only X chromosome came from her mother, who was a carrier.
C. The daughter could not have inherited Lesch-Nyhan because neither of her parents have the disease. The fact that her great-grandfather had Lesch-Nyhan is a coincidence.
D. The daughter is XO. Her only X chromosome carries the Lesch-Nyhan mutation and was inherited from her father, who was a carrier.
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