Glycogenolysis and glycogen synthesis are regulated in such a way that neither process is active at the same time. During the fasted state, (ratio of insulin to glucagon is low) which of the following best characterizes the regulation of these pathways:

A. Both glycogen phosphorylase and glycogen synthase are phosphorylated
B. Both glycogen phosphorylase and glycogen synthase are dephosphorylated
C. Glycogen phosphorylase is phosphorylated and glycogen synthase is dephosphorylated
D. Glycogen phosphorylase is dephosphorylated and glycogen synthase is phosphorylated

Explanation:

Both, the  glycogen phosphorylase and glycogen synthase are phosphorylated .

In the fasted state both enzymes are phosphorylated. Glycogen phosphorylase is phosphorylated and active. Glycogen synthase is phosphorylated and inactive.

Glycogenolysis: the process of breakdown of glycogen to glucose-1-phosphate and glycogen (n-1), by the enzyme glycogen phosphorylase.

Glycogen synthesis;

The pathway of  glycogen synthesis, synthesis of glycogen from glucose subunits.

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