An NP student did a medication reconciliation while taking a history. The patient has been taking sucralfate [Carafate] and Amoxicillin to treat peptic ulcer disease. The student asks the NP about the pharmacokinetics of sucralfate. Which statement by the student indicates a need for further teaching?

a."Sucralfate adheres to the ulcer and blocks the back-diffusion of hydrogen ions."

b."Sucralfate and ciprofloxacin should be administered 1 hour apart."

c."Sucralfate does not cause systemic side effects."

d."Sucralfate has a moderate acid-neutralizing capacity.

D.

Explanation:

Peptic  Ulcer is caused by activities of Helicobacter  pyroli , and  wearing(erosion)  of the gastric mucosa of the G.I. This causes inflammation of the  localized part of the  stomach . This results in pain from the sores produced

. Anagelsics, is given  reduce pain, antibiotics to kill the bacteria, and medication to neutralized elevated acids and  suppress it  are usually administered.

Therefore, any drug that will not neutralize the elevated  acid effects of the stomach HCL acid should not be administered.

Sucaralfate lacks acidic neutralizing capacity, needed to suppress the acidity of the G.I by blocking efflux of H+ ions ., therefore it is the Odd option in the group.

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