G What will be the effect of the overexpression of this truncated receptor? EGFR will dimerize but will not cross‑phosphorylate, inhibiting normal cell growth. EGFR will be unable to bind its ligand, blocking the signal and stopping cell growth. EGFR will activate other proteins without dimerization, causing uncontrolled cell growth. EGFR will not form a dimer in the presence of EGF, stopping normal cell growth.

Explanation:

EGFR gene :

Epidermal growth factor receptor,

-which spans the cell membrane so that one end of the protein remains inside the cell and the other end located outer surface of the cell. This causes receptor to attach ligands, and to receive signals ,by which cell respond to its environment. Epidermal growth factor receptor binds to many different type of receptors. The binding of a ligand to receptor allows the receptor to attach to another nearby epidermal growth factor receptor protein (dimerize), activating the receptor complex. As a result, signaling pathways within the cell are triggered that promote cell growth and division and cell survival. If there is abnormlty in the expression of EGFR gene  , then the cell show uncontrolled growth.

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