The enzyme acetylcholinesterase, located in the synaptic cleft and on the postsynaptic membrane, breaks ACh down into acetate and choline, thereby stopping the stimulation of a postsynaptic cell. True / False.

True

Explanation:

The action of aceetylcholine in the synaptic cleft is normally terminated by metabolism to acetate and choline by the enzyme acetylcholinesterase and the stimulation of the post-synaptic cell is stopped.

This esterase is anchored to the postsynaptic cell but acts extracellularly.

The products of acetylcholinesterase are not released , infact they are reabsorbed to make more ACh.

Hence, the statement the enzyme acetylcholinesterase, located in the synaptic cleft and on the postsynaptic membrane, breaks ACh down into acetate and choline, thereby stopping the stimulation of a postsynaptic cell is true.

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