Thomas is studying his family’s genealogy for an anthropology class. He interviews an uncle about the family’s health history and learns that a number of family members have sickle cell anemia. It is safe to assume that:.

The question is incomplete as it does not have the options which are:

A) Tomas' family is of Asian descent.

B) Tomas' family members with sickle cell anemia have a defect in the structure of the protein chains of hemoglobin.

C) Tomas' family historically has consumed a low-protein diet.

D) All of the above are true.

Option-B

Explanation:

Sickle cell anaemia is a disorder which is caused by the mutation of the sequence of the DNA which codes for haemoglobin.

The mutation takes place at sixth position in which the glutamic acid codon is changed to valine codon. This mutation changes the shape of the  hemoglobin.

This mutation changes the shape of the haemoglobin molecule from circular ellipsoidal to sickle shape and thus reduces the amount of oxygen in the blood.

In the given question, if the person studies that many family members of Thomas have this disease therefore it can be predicted that the haemoglobin protein in them will be changed to a sickle shape.

Thus, Option-B is correct.

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