Enterochromaffin-like cells of the gastric mucosa can be triggered to release histamine. Histamine, in this case, causes nearby parietal cells of the stomach lining to produce hydrochloric acid. The effect of histamine on parietal cells would best be described as a(n) .

The correct answer is - paracrine.

Explanation:

Paracrine is type of signalling in which a cell cause a signal to trigger changes in nearby cell and change the nature or action of those cells. It is cell to cell communication by the mediators that are released from a cell and bind to neighbor cell receptors to cause their effect.

Histamine is a hormone that is released by the Enterchromoffin like cells and act on the neighbor parietal cells to release HCl acid.

Thus, the correct answer is - paracrine.

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