In most cases, mutations in the core of a protein that replace a smaller nonpolar side chain in the wild-type (e. g., Ala, Val) with a larger nonpolar side chain (e. g., Leu, Ile, Phe, Trp) in the mutant, result in significant destabilization and misfolding of the mutant. What feature of the protein core explains this observation? Why would such a mutation prevent a protein from folding properly?Interactions of side chains in the protein sequence lead to the formation of a tightly packed core. This core is stabilized by a number of . When a mutation occurs, it destabilizes the protein core and weakens leading to misfolding. a. hydrogen bondsb. polarc. larged. van der Waals contactse. hydrophobicf. disulfide bridgesg. hydrophilich. smalli. nonpolar

Emmet didn’t want to weed the garden. he put off the task toward the end of the day. he even tried to get his sister to do the job. what type of goal orientation did emmet display toward weeding the garden?

Diego conducted an experiment to find out what kind of ball bounces the highest when dropped from a five-foot platform. he used a golf ball, a tennis ball, and a soccer ball. he dropped each ball from the balcony once. diego recorded his observations after each drop. what can diego do to best improve the reliability of his results? a) drop each ball from the platform three more times b) record his observations in more than one unit c) write at least two scientific questions after the experiment is complete d) share his results with other people who have done similar experiments you for the !

He did not infringe upon the policy making powers that he felt the constitution gave congress. but the determination of foreign policy became preponderantly a presidential concern. when the french revolution led to a major war between france and england, washington refused to accept entirely the recommendations of either his secretary of state thomas jefferson, who was pro-french, or his secretary of the treasury alexander hamilton, who was pro-british. rather, he insisted upon a neutral course until the united states could grow stronger. which provides the best objective summary of this excerpt? president washington made a good choice when he decided not to accept the recommendations of his advisors and instead insisted that the united states stay neutral during the war between france and england as president, washington believed that the united states should remain neutral in foreign policy even though he had advisors who recommended that he take sides during the war between france and england. washington did not make policy decisions during his presidency because he did not want to interfere with the policy-making powers that the constitution gave congress. washington refused to accept entirely the recommendations of either his secretary of state thomas jefferson, who was pro-french, or his secretary of the treasury alexander hamilton, who was pro-britis