Water is prevented from entering the active site of glycogen phosphorylase. What are the advantages of excluding water from the active site? to prevent the unnecessary breakdown of glycogen to maintain energy supplies in muscle cells to prevent the formation of glucose to prevent energy waste by conserving the ATP ATP that would be needed to phosphorylate glucose to prevent hydrolytic cleavage of glucose 1‑phosphate

to prevent the formation of glucose,

to maintain energy supplies in muscle cells

to prevent energy waste by conserving the ATP ATP that would be needed to phosphorylate glucose

Explanation:

Glycogenlysis,the  breakdown  of glycogen involves the activities of glycogen phosphorylase. This enzyme phosphorylated glycogen to glucose-1-phosphate. The latter in  presence of  enzyme phosphoglucomutase is  converted to Glucose-6-phosphate. (GP6)

GP6  enters glycolysis straight, to produce pyruvate.This  step   has shunted ATPs   consumption  of the usual  glucose phosphoryaltion   of  the glycolytic pathway , thus  conserving more energy for the muscles cells.

However if the glycogen phosphate active site was exposed to water, it will  be hydrolyzed to glucose,( instead of glucose-1-phosphate).The glucose  will   pass through the normal ATPs consuming  glycolytic pathways, losing more energy.

Therefore to prevent glucose formation,  to conserve energy  for  immediate availability to  ever demanding muscles cells, water is excluded from the active site of glycogen phosphorylase.

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