To accurately estimate genetic distance as a measure of the actual number of substitutions that have occurred one must adjust the observed fraction of substitutions because (select all that apply):

(A) Single substitutions are tedious to count and one wants to adjust for errors one make in counting.
(B) Parallel substitutions in multiple sequences obscure where changes have occured.
(C) Convergent substitutions result in changes in multiple sequences that would not be observed.
(D) One can have sequential substitutions in a sequence over time.

Atp is is our little "pocket" of energy. of course, if you have too little, then it means you have too little energy, and you'll pass out. the way to not have enough, is to have no energy sources (glucose, fats, proteins). you can't have too many atp molecules. cycles like the krebs cycle produce it, but if you have too much of any substrate (or too little for that matter), the cycle stops and atp is no longer made (it stops until substrate levels are such that the process can go on). in any case, this is unlikely since atp is constantly hydrolyzed and remade, even while you're asleep. you won't have too much. if you have zero, you are dead or dying.