For some Gram-negative bacterial infections, antibiotic treatment can cause a more severe reaction than that caused by the base infection. This is often due to the release of endotoxin from the cell. Endotoxin, or LPS, is harmless in intact pathogens but can cause dangerously low blood pressure and high fever once released.

Which antibiotic here would you recommend against a bacterial pathogen that encodes LPS?

a) polymyxin, because it inserts into the cell membrane, disrupting homeostasis.

b) tetracycline, because it targets bacterial ribosomes.

c) vancomycin, because it disrupts cell wall formation.

d) ethambutol, because it interreupts arabinogalatcan.

Polymyxin because, it inserts into the cell membrane and disrupts homeostasis.

Explanation:

Antimicrobial effect reacts with the cell membrane of the gram negative bacteria and causes disruption in their cell membrane by creating pores.

The cell membrane of bacteria release endotoxin for creating defense mechanism.

But the effect of certain antimicrobial peptide disrupt the effect of membrane by releasing electrostatic interaction and creates membrane pores.

The interaction between the microbial peptide and the cell membrane causes disruption of the cell.

Thus polymyxin is used to treat against the gram negative bacteria as they breaks the cell membrane of the bacteria.

what are the choices?

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