When first introduced by Fritz Lipmann in 1941, the term high-energy bond was considered a useful concept for describing the energetics of biochemical molecules and reactions. However, the term can lead to confusion when relating ideas about cellular energy metabolism to those of physical chemistry. To check out your own understanding, indicate whether each of the following statements is true or false. Drag the appropriate items to their respective bins.

To a physical chemist, high-energy bond means a vary stable bond that requires a lot of energy to break, where as to a biochemist, the term is likely to mean that a release of a lot of energy upon hydrolysis.

Explanation:

FALSE

Energy can be stored in special high-energy bonds in molecules such as ATP and is released when these bonds are broken no such thing as a high-energy bond, it’s all about the stability of reactant vs product or something to that effect.

The terminal phosphate of ATP is a high-energy phosphate that takes its high energy with it when it is hydrolyzed-The phosphate group doesn't posses any intrinsic energy of its own. The term high-energy applies only to the phosphoanhydride bond that links the phosphate group to the rest of the ATP molecule.

Phosphoester bonds are low-energy bonds beacuase they require less energy to break than the high-energy bonds of phosphoanhydrides.- the low-energy bonds require more energy to break, which is why less energy is released when such bonds are hydrolyzed.

TRUE:

The term high-energy molecule should be thought of as a characteristic of the reaction  that the molecule is involved in – not as an intrinsic property of a particular bond within the molecule.

b

Explanation:

However, the term can lead to confusion when relating ideas about cellular energy metabolism to those of physical chemistry.

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