The occurrence of the NN blood group genotype in the US population is 1 in 400, consider NN as the homozygous recessive genotype in this population.
You sample 1,000 individuals from a large population for the MN blood group, which can easily be measured since co-dominance is involved (i. e., you can detect the heterozygotes). They are typed accordingly:

BLOOD TYPE

GENOTYPE

NUMBER OF INDIVIDUALS

RESULTING FREQUENCY

M

MM

490

0.49

MN

MN

420

0.42

N

NN

90

0.09

Using the data provide above, calculate the following:
The frequency of each allele in the population.
Based on HWE what are the expected frequencies for the three genotypes
Are the observed frequencies different than the expected frequencies?


Cystic fibrosis is a recessive condition that affects about 1 in 2,500 babies in the Caucasian population of the United States. Please calculate the following.
The frequency of the recessive allele in the population.
The frequency of the dominant allele in the population.
The percentage of heterozygous individuals (carriers) in the population.
A lethal recessive condition is responsible for the death of 1 out of every 20,000 babies born in South America.
a. What is the frequency of the recessive allele in the population?

b. What is the frequency of the dominant allele in the population?

c. What is the frequency of homozygous recessive individuals in the population?

d. How many people, out of 1,000 individuals in this population, would carry the recessive allele?