Taking into account your knowledge of wobble rules, which of the following anticodons could pair with the codon 5'-uac-3'? (select all that apply.)a. 5'-iua-3'b. 5'-gui-3'c. 5'-gua-3'd. 5'-aug-3'

The codon 5'-UAC-3' can pair with the anticodon 3´- AUI-5´ or with the anticodon 3´- AUG-5´.

Explanation:

The wobble hypothesis explains that the same anticodon can interact with different codons that differ in their third base. This is, bases 3 from the 3´extreme and bases 2 from the middle in the anticodon recognize the first base from the 5´extreme and the second one from the middle in the codon, according to the Watson and Crick pairing rules: Adenine pairs with Thymine and Guanine pairs with Cytosine.  But on the other hand, the first base from the anticodon 5´extreme is less selective and can stablish a pair with the third base from the codon 3´ extreme according to Watson and Crick model or might stablish a different pair. This is, Guanine can pair with uracil or cytosine in the codon. Uracil can pair with adenine or guanine in the codon. Hyoscine can pair with adenine, cytosine or uracil in the codon.  

According to this, the codon 5'-UAC-3' can pair with the anticodon 3´- AUI-5´ or with the anticodon 3´- AUG-5´.

Codon                5´-UAC-3´

Anticodon         3´-AUI-5´   The first base from the anticodon 5´extrem (Hyoscine) establishes a pair with the third base from the codon 3´ extreme (Cytosine), according to the wobble hypothesis.

                             3´-AUG-5´  The first base from the anticodon 5´extrem (Guanine) establishes a pair with the third base from the codon 3´ extreme (Cytosine), according to the Watson and Crick model.