Many enzymes require metal ions as cofactors due to the inherent properties of the metal ion. metal ions, when bound to water, will favor the formation of hydroxide ion, which is a strong nucleophile. therefore the activation of water for nucleophilic reactions such as hydrolysis is one property of metal ions that assists in catalysis. what is another?

Another property of metal ions that assists in catalysis is stabilization of negative charge transition states.

A few properties of metal ions that assists in catalysis are is its ability to orient a substrate and perform reversible oxidation-reduction reaction as seen in redox catalysis.

Explanation: The combination formed by an enzyme and its substrates is called the enzyme–substrate complex.

In catalysis as acid, base and salt reaction .Although metal-assisted hydrolysis of lipids remains relatively unexplored, it is undoubtedly of equal importance.

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