Fill in the blanks: 1. enzymes are whose three-dimensional shape is dependent upon environmental variables, including temperature. 2. enzymes function most efficiently at temperatures. 3. temperature increases caused by fever result in efficient enzyme activity and enzymes are able to make product in a given period of time. 4. this occurs because increased energy of molecules enhances substrate and enzyme contact. 5. severe increases in temperature the bonds that hold an enzyme's shape. 6. the enzyme subsequently , permanently function.