Although there are 61 codons in the universal genetic code that specify amino acids, most organisms possess fewer than 45 different trnas. some trnas can be used to read different codons due to flexibility in the base pairing of the mrna codon and the anticodon. these "wobble" base pairs allow for non watson crick hydrogen bonding, and therefore allow a single trna to read multiple codons.

which of the following best describes the structural basis of the wobble hypothesis? (2 is incorrect)

1. the pairing of the third (3') base of the mrna codon and the third (3') base of the trna anticodon are less constrained by base stacking.
2. the pairing of the first (5') base of the mrna codon and the third (3') base of the trna anticodon are less constrained by base stacking.
3.the pairing of the first (5') base of the mrna codon and the first (5') base of the trna anticodon are less constrained by base stacking.
4. the pairing of the third (3') base of the mrna codon and the first (5') base of the trna anticodon are less constrained by base stacking.