Which of the following general statement(s) about a g protein–coupled receptor is (are) true? a. it contains 12 transmembrane domains. b. it is positioned with the n-terminus on the cytoplasmic face of the membrane. c. it is positioned with the c-terminus on the cytoplasmic face of the membrane. d. all of the above.

c. It is positioned with the C-terminus on the cytoplasmic face of the membrane.

Explanation:

G protein-coupled receptor or GPCR is a protein receptor. It is present only in eukaryotes. It is part of two main signal transduction pathways: phosphatidylinositol signal pathway and cAMP signal pathway. When a ligand binds to it, there is a confirmational change in it which leads to activation of G protein.

GPCR is an integral membrane protein receptor and has seven transmembrane (membrane spanning) domains. N terminus (NH2 part) of the receptor is extracellular and C terminus (COOH part) of the receptor is cytoplasmic. Hence option c is correct.  

i think that you are smart and you should fit for it out