What must eukaryotes do to initiate transcription of a gene?

a) bind rna polymerase to displace histone proteins that binding dna in the promoter region.
b)recruit general transcription factors to produce an open complex and then recruit rna polymerase.
c)recruit the transcription factors and rna polymerase that compose the pre-initiation complex.
d)open the dna template and then bind rna polymerase at the transcriptional initiation site.
e) bind transcription factors from enhancer sequences to the rna polymerase.

c)Recruit the transcription factors and RNA Polymerase that compose the pre-initiation complex.

Explanation:

Transcription leads to formation of RNA from DNA. The process is carried out by RNA Polymerase which forms a RNA strand according to the template DNA strand.

It starts by the formation of pre-initiation complex. RNA Polymerase along with transcription factors binds to the promoter region of DNA and forms the pre-initiation complex. Generally the eukaryotic promoters have a sequence called as TATA box where the transcription factors bind first. Eventually RNA polymerase also binds to the region and the DNA strands separate starting the transcription process.

an individual’s sex (i.e., whether they are a male or female) is determined by the sex chromosomes. most people have two sex chromosomes, one that is inherited from their mother and one that is inherited from their father. typically, females have two x chromosomes (xx) and males have one x chromosome and one y chromosome (xy). conditions caused by changes (“mutations”) in genes located on the x chromosome are considered x-linked.

x-linked recessive inheritance

most x-linked conditions are recessive. this means that in a person with two x chromosomes (most females), both copies of a gene (i.e., one on each x chromosome) must have a change or mutation whereas in a person with one x chromosome (most males), only one copy of a gene must have a mutation. a female with a mutation in one copy of a gene on the x chromosome is said to be a “carrier” for an x-linked condition. a male with a mutation in a gene on the x chromosome is typically affected with the condition. because females have two copies of the x chromosome and males have only one x chromosome, x-linked recessive diseases are more common among males than females. however, x-linked recessive diseases can occur in both males and females.

for x-linked recessive disorders, an unaffected carrier mother who has a mutation in a gene on the x chromosome can transmit either the x chromosome with this mutation or a “normal” x chromosome to her children. if the father is unaffected, none of her daughters will be affected and all of her daughters will be unaffected—since they will inherit at least one normal x chromosome from their father. however, each daughter will have a 50% chance of being an unaffected carrier like her mother and a 50% chance of both x chromosomes being normal.