An unaffected man whose mother had sickle-cell anemia marries an unaffected woman whose father had sickle-cell anemia. which of the following statements about their offspring is not true?
a. about 75% can be expected to have the sickle-cell allele.
b. they must all have the sickle-cell trait.
c. about 50% can be expected to be heterozygous for the sickle-cell allele.
c. they may not have either sickle-cell trait or sickle-cell anemia.

Mr. j, age 42, is a construction worker in las vegas. he recently noticed that a mole on his face seemed to be getting larger and darker. at first he did not worry because he was in the sun a lot and assumed the change may have been caused by sunburn. after a month, not only was the mole larger and darker, but it appeared to be “bumpy.” his doctor diagnosed a malignant melanoma skin cancer following biopsy of the nevus. mr. j reports pain in his right shin that does not go away when he puts his feet up or sleeps. discussion questions 1. relate mr. j’s skin changes to the warning signs for malignant melanoma. (see malignant melanoma.) 2. discuss the normal progression of this malignancy. what is the significance of the bone pain that mr. j is experiencing? (see malignant melanoma.) 3. discuss the treatment available for this patient and the prognosis for recovery. (see malignant melanoma.)