The control of which enzyme exerts the most control on glycolysis?
hexokinase
phosphofructokinase
glucose-6-phosphatase
aldolase

phosphofructokinase

Explanation:

Phosphofructokinase 1, also known as PFK-1, is the second glycolysis regulatory enzyme and its main regulatory point. Therefore we can state that this enzyme is exerts the greatest control over glycolysis.

Phosphofrutokinase is an allosteric enzyme belonging to the phosphotransferase family that catalyzes a phosphorylation: the conversion of fructose-6-phosphate and ATP into fructose-1,6-bisphosphate and ADP, a key step in regulating and limiting glycolysis rate in response to the cell's energy needs through the allosteric inhibition process

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