The substitution of a t for an a in the protein coding sequence of the globin gene introduced a snp. this snp changed an amino acid resulting in sickle cell anemia. unaffected individuals have the dna sequence gaggag, a bseri restriction enzyme site, in their gene generating two dna fragments of 2 and 4 kb. the a to t substitution occurs within the bser1 site thus inactivating the site (gtggag). draw the rflp gel including results for a carrier, as well as homozygous normal and affected individuals.

Sickle cell anemia refers to a recessive inheritance disorder, in which every individual carries two copies of a gene. In normal individuals, both the copies of the globin gene are normal, and they generate 2 and 4 kb fragments of DNA on digestion by BseR1. A patient with sickle cell anemia is homozygous for the recessive gene and exhibits a mutation in both the copies of a globin gene.  

Therefore, BseR1 could not digest the globin gene and generate a single 6Kb fragment of DNA. In a patient acting as a carrier, one copy of a globin gene is mutated and the other is normal. As a consequence, BseR1 digestion generates 6kb of the fragment of DNA (mutated copy) and 4 and 2 kb from the normal copy of a gene.  

videntify the dna change shown in the diagram and explain how that change can result in the increased genetic diversity often seen among siblings.identify the dna change shown in the diagram and explain how that change can result in the increased genetic diversity often seen among siblings.

albert einstein retrieved guacamole from the galapagos islands in africa