What negative effect does sickle-cell disease have on the circulatory system?

Because sickled cells restrict blood flow, individuals can periodically experience swelling and extreme pain in any body organ or joint. This can last for hours or weeks. Sometimes permanent damage can occur to organs deprived of oxygen and nutrients

Explanation:

Red blood cells are designed to pick up oxygen in the lungs and transport it throughout the body via the circulatory system. Their donut-like shape and water-balloon-like flexibility allows them to pass through even the tiniest blood vessels.

Sickle cell anemia is a hereditary condition that causes some red blood cells to distort into rigid crescent moon shapes.

Normal red blood cells can flow freely through blood vessels. Sickled cells get stuck in the blood vessels and cause blockages.

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