How do cells know that there is something wrong with the dna?

The short answer is that cells respond to the chemical environment in which they find themselves. The cells around them, the specific conditions, and feedback from the environment all create specific chemical cues that inform the cells to which genes should be expressed, and in what amounts. Chemicals include hormones, cytokines, general signaling molecules, such as cAMP, etc.

i literally hopped on google for this, lol.
i hope this helps though. :)

Heyhonestly, probably not. humans have always had a tendency to waste things. whether it's food, cosmetic, infrastructure, or our abandoned constructions,the landscape is littered with the refuseof man. archaeology wouldn't be a developed discipline if humans didn't leave things behind. in a way it makes us human

hope it mark me as brainlieast.