What was dr. willem johan kolff’s first step in using the scientific process to invent the hemodialysis machine? he built the machine and tried it with various patients, collecting data about its effectiveness. when a patient’s kidneys failed, he wondered if it would be possible to perform kidney functions with an external machine. he researched and collected data about numerous patients who exhibited symptoms of kidney failure. he drew conclusions from studies of various symptoms of kidney failure, and drew a design for the ideal external blood-processing machine.

Choose the incorrect statement (a) the motor end plate membrane is only capable of generating graded potentials, but it is contiguous with the skeletal muscle sarcolemma, which can generate action potentials. (b) propagation of an action potential through the t-tubules into the sarcoplasmic reticulum triggers the release of ca++ into the cytoplasm of a skeletal muscle fiber. (c) the generation of suprathreshold endplate potentials in multiple muscle fibers could be due to the increased frequency of action potential generation at the axon hillock of a single motor neuron. (d) a greater amount of ach would be found in the presynaptic vesicles of a motor unit that fired several action potentials after exposure to botulinum toxin, than in a motor unit that fired several action potentials after exposure to the venom of the krait snake (which contains α-bungarotoxin).