Sickle cell disease is passed on from parent to offspring. sickle cell disease is an disease. some carriers of the disease exhibit increased resistance to malarial parasites. this resistance is a mutation. part a 1. inherited 2. acquired part b 1. neutral 2. harmful 3. beneficial

Part A : 1. Inherited

Part B : 3. Beneficial

Explanation:

Sickle cell anemia is a disease that is inherited from parents to offspring. This disease is characterized by painful events like anemia,organ and tissue damage and other such complications.

Due to this disease RBCs are rapidly lost from blood prior to they go for circulation, therefore it is called as hemolytic  disorder because it destructs cell membrane of RBCs  results in the release of hemoglobin.

There is another interesting fact about Sickle cell anemia. The disease is caused by a mutation in a gene, and the disease is genetically recessive which means you need two mutated genes to develop Sickle cell Anemia, However, if you are carrier of disease but healthy, then you will be resistant to the deadly disease Malaria.This mutation increased the likelihood that carriers  for sickle cell disease will survive malaria infection.

Hope it helps!

enzyme active site and substrate specificity

enzymes bind with chemical reactants called substrates. there may be one or more substrates for each type of enzyme, depending on the particular chemical reaction. in some reactions, a single-reactant substrate is broken down into multiple products