20 answer, ! describe how a substrate interacts with an enzyme. use the phrase lock and key in your description.

The specific action of an enzyme with a single substrate can be explained using a Lock and Key analogy first postulated in 1894 by Emil Fischer. In this analogy, the lock is the enzyme and the key is the substrate. Only the correctly sized key (substrate) fits into the key hole (active site) of the lock (enzyme).

Smaller keys, larger keys, or incorrectly positioned teeth on keys (incorrectly shaped or sized substrate molecules) do not fit into the lock (enzyme). Only the correctly shaped key opens a particular lock. This is illustrated in graphic on the left.

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in 1859, charles darwin set out his theory of evolution by natural selection as an explanation for adaptation and speciation. he defined natural selection as the "principle by which each slight variation [of a trait], if useful, is preserved".