What is the difference between a nucleoside tetraphosphate and a tetranucleotide? what is the difference between a nucleoside tetraphosphate and a tetranucleotide? a nucleoside tetraphosphate yields upon complete hydrolysis one nucleobase, one sugar, and four phosphates. a tetranucleotide yields four bases, four sugars, and at least three phosphates. a nucleoside tetraphosphate yields upon complete hydrolysis one nucleobase, four sugars, and at least three phosphates. a tetranucleotide yields four nucleobases, one sugar, and four phosphates. a nucleoside tetraphosphate yields upon complete hydrolysis four nucleobases, one sugar, and four phosphates. a tetranucleotide yields one base, four sugars, and at least three phosphates. a nucleoside tetraphosphate yields upon complete hydrolysis four nucleobases, four sugars, and at least three phosphates. a tetranucleotide yields one base, one sugar, and four phosphates?