Bacteria become antibiotic-resistant over time as a result of

Antibiotic resistance is the ability of microbes to resist the effects of an antibiotic. Antibiotic resistance in the microbes or bacteria occurs when bacteria change in a way that the effectiveness of drugs, chemicals, or other agents designed to cure or prevent infections is reduced or eliminated. The bacteria survive and continue to multiply causing more harm.

an active site is a region that is present on an enzyme where the reactants or the substrate molecules we can say bind and experience a chemical reaction. the substrate is basically a reactant whose concentration is changing and that is converting into a product after binding at the active site of an enzyme